翻译了一篇Medhelp
Hello Doctor Hunter.Please help me with some clarifications about the HIV window period because I am desperate and don't know what to do any more.
I had an unprotected brief sexual enconter about 6 months ago. Since then I've had several HIV tests and a lot of sleepless nights. I had a PCR RNA and DNA at 3, 6, 8 and 13 weeks, DUO tests with antibodies and antigen at 6, 10, 13 and 26 weeks, and antibodies tests just about every week from 1 month to 6 months. My test were negative. The reason why I kept testing beyond your indicated 3 months period was because I was told by the laboratory that I have to repeat my antibodies tests which are the most accurate up until 6 months. Now I have gone for my 6 monts test (DUO) which was negative again and they said I have to repeat it at 1 year, just to be extra sure. This term "extra sure", for me means that the test I have done are not yet conclusive. Of course I cannot continue my life until I have a conclusive test. I'm even afraid to go to the dentist with a 2 month long aching tooth because I'm afraid not to put him at risk as I am not sure yet that I'm negative. I don't know what to do anymore, I cannot sleep or eat. A simple search on the internet for seroconversion beyond 6 months shows at least 10 people saying that they have had several test but have not seroconverted up until 7, 12, 18 or even 30 months. I don't know what to do any more, I'm just inclined to keep testing and continue with my abstinence and care so that I will not put anyone at risk. I keep checking my bodies for signs. When will I know whether I'm positive or negative? Please tell me what are the statistics are here.Please understand my state of mind, I'm desperate. Yesterday while taking a bath i noticed a bleeding scratch on my knee and i spent an hour washing and disinfecting the bath tub just for fear of putting other people of risk. Please help me with some answers...
医生你好：
请帮我解释一下一些关于HIV窗口期的问题，因为我感觉非常绝望不知道该咋办了。
在六个月前我曾有过短暂的无套性接触。从那之后我检测过很多次并且经常失眠。我曾经在第3、6、8、13周做过PCR RNA和DNA检测（不是很懂，但应该是核酸检测），在6、10、13、26周做过双重检测（DUO test就是抗体和抗原一同检测的方法，四代酶联就是其中一种），并且基本上从第一个月到第六个月每周都会做一次抗体检测（快速法）。我的检测结果都是阴性。我之所以超过您所声明的三个月窗口期而一直检测是因为，我做检测实验室让我一直做到六个月，这样才能使得检测的准确度最大。现在我做过六个月的检测了，并且结果是阴性，而他们说我需要在一年的时候复检，只是为了保证额外的精度。这种“额外的精度”，对我来说就意味着我所做的检测得到的结果并不是决定性的。当然我拿不到决定性的结果我就没办法继续我的生活。我甚至不敢去看牙医，为此我忍受了两个月的牙痛，因为我还不能完全确定自己是阴性的怕给医生带来危险。我不知道该怎么办了。我在网上随便一搜“6个月后抗体产生”，就发现至少有十个人生成他们做了一些检测都为阴知道第7周、第12周、18周甚至有人说30周转阳。我不知道该怎么办了，我打算继续检测，过着害怕节欲的生活，因为只有这样我才不会给别人带来危险。我不停检查我的身体有没有什么感染的迹象。我什么时候才能知道我到底是阴是阳。请告诉我这里的一些数据，请您理解我的心情，我非常的绝望。昨天我洗澡的时候我发现在我膝盖上有一处抓伤。我花了一个小时给清洗、消毒浴缸。我害怕给别人带来危险。请帮我回答这些问题。
（善良的咨询者，坑爹的检测机构啊！）
Edward W Hook, MD
Mar 19, 2012
Welcome to the Forum.I will be answering your question.
I'm sorry to hear of your distress, particularly since it is unwarranted.I am not sure of your information sources but I can tell you that with modern testing I know of no HIV seroconversions which have taken more than 8 weeks to occur following exposure.The recommendations for testing at 3 and even 6 months or beyond are the result of two factors- data from older tests no longer used (you really do not need to worry about which generation of tests you were tested with, at this time virtually all tests are far more sensitive that they were even 3-5 years ago when the 3 month recommendation was made) and secondly, the fact that some, mostly governmental agencies which have to provide recommendations for virtually everyone without the sort of interactions such as those you get with your doctor or onsuch as this one, feel they cannot "afford" to be wrong and therefore make recommendations and guidelines which leave most people unnecessarily nervous for 4-6 weeks longer than the 6-8 weeks it takes virtually everyone to develop HIV antibodies. Labs like these recommendations since more testing is good for their business.
Unfortunately the internet is full of mythology about prolonged "window" periods and delayed seroconversion which reflect either old data or which are unsubstantiated.Neither of us is aware of ANY reports of seroconversion taking more than 8 weeks for a number of years, either in the published scientific literature or in discussions with other experts.
I hope my comments are helpful.You need to believe your tests and move on.You did not get HIV from the exposure you mention.
欢迎来到本论坛。我来回答你的问题。
看到你有这么大的压力，特别是知道了这些压力的来源都是无根据的时候，我感到十分的遗憾。我无法知道你的信息来源，但我可以告诉你，根据现今的检测技术，据我所知没有一例HIV的血清转换是发生在8周以后的。关于在三个月、甚至六个月或六个月以后的检测的建议，我觉得主要是出于以下两个原因：（1）他们的数据是根据一些不再被使用的旧的检测方法得来的（你不必担心你做的第几代的检测，目前所有的方法都要比3-5年前3个月这个窗口期制定的时候的方法要敏感的多。）（2）事实上通常一些ZF机构必须给所有人提供建议，而有些人不像你有你的医生可以咨询或者你可以来像Medhelp这样的私人网站进行咨询。而这些机构不能“承受”犯错，所以他们提供的建议往往要比几乎所有人都可以产生抗体的时间6-8周要长。这些建议使得那些没有其他途径可以咨询的人白白的多焦虑上4-6周。那些实验室喜欢提出这样的建议是因为大家都来做测试，他们自然会有好生意。
很不幸，网上充满了各种关于“延长窗口期”和推迟的血清转换的各种神话，这些现象的来源往往要不然是十分陈旧的数据，要不然就是未经证实的。我们从未从一些发表的科学文献或者与其他专家交流的过程中听说有任何关于8周之后转阳的报告。
希望我的评论对你有所帮助，你要相信你的检测结果，并且好好生活。你没有感染HIV。
翻译的很有水准:lol 良哥辛苦啦！给广大恐友带来福音！！！！这个必须顶啊！！！ 这是一位在读研究生帮助翻译的。我英语不行啊。;P
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