求高手进来解释曹教授说世界上7个人在血液中查不出抗体的原因啊
例如，有的患者问，都说存在阴性感染者，那么我们会不会也存在这种情况呢？首先，阴性感染者，是确实存在的，国内著名权威专家曹韵贞教授说过，在全世界5300万感染者中，只有7个阴性感染者存在。既然世界范围，5300多万人，只存在7个，说明这是极其特例的。根据概率来算是大海捞针。而且，这7个人，只是通过血液检测不出来，尿液检测，是可以检测出来的。看了这我很恐惧，恐慌，有知道的能解释下吗 这7个人后来在血检中查出来了吗？ 死钻牛角尖你觉得有意思吗？那世界上还有HIV被治好了呢，你怎么不想想好的。死钻牛角尖。世界上很多种罕见的疾病啊，比HIV恐怖很多呢，你怎么不担心的？ 楼主你这是轻微的强迫症的表现。世界之大无奇不有。
举个例子。很现实深刻的例子。
流感病毒引起的感冒，全世界大约有96%的人可以治愈，剩下的4%会引起严重的并发症导致死亡。
跟你说的这个比，哪个概率大？
你从小到现在几十年了，哪年不感冒？
但是真正死过几次了？ 我也想知道答案啊 楼主，你觉得某天飞机失事，会正好砸在你头吗？ 某天火车出轨，会正好飞你脸上吗？ 这种低概率的事根本没有讨论的价值，就像你认为母猪会爬树一样，根本不可能会发生在你身上。 这个谈话时间较早，当时使用的仍然是酶联二代试剂。
现在的试剂敏感度和特异性大大增强，漏检的可能性基本为0。
最后，人体不是机器，以60亿的样本来说，出现几个变异是很正常的事情。你不能以感染者人数作为分母来看待这种变异，而是要以整个人类作为分母来看待问题。所以，你所担心的事情是60亿分之7，这种概率你有担心的必要？？ 这种几率比买中**的几率还要低呢。。 没有意义，都什么时候的事了，还拿出来讨论！！ To compare the Western Blot (WB) patterns of paired urine and serum samples from subjects who tested repeatedly reactive in an investigational urine HIV-1 antibody EIA test and negative on a licensed serum HIV-1 antibody EIA test. METHODS: 7,607 paired urine and serum specimens were obtained from subjects at low and high risk for infection with HIV-1 from the U.S. and Haiti and tested by multiple centers. A portion of these specimens were linked as to donor identity. Neat urine specimens were tested in an investigational EIA employing an HIV-1 recombinant envelope protein, with confirmation of repeatedly reactive specimens using a modification of a licensed WB procedure. Serum specimens were tested by licensed EIA, with confirmation of repeatedly reactive specimens using a licensed WB procedure. RESULTS: Of 1,804 subjects participating in the linked study, 7 were urine EIA repeatedly reactive, urine WB confirmed positive and were serum EIA negative. On WB, 3 ofthe 7 serum samples demonstrated a positive p24 band. One of these 3 samples came from a 41 yr old female atrisk for HIV infection, one from a35 year old female with SLE andone from one a 16 yr old male with acute glomerular nephritis. Of the remaining 4 samples, two were from female sexual partners of HIV-1 positive persons, one from a male with non-gonococcal urethritis and one from a female with Hodgkin's Disease. Of the 5,803 unlinked subjects, two samples were found to be urine EIA and WB positive and serum EIA and WB negative. CONCLUSION: The WB confirmed presence of urine HIV-1 envelope antibody is highly suggestive of an HIV-1 infection. Four out of seven WB reactive urine samples were from EIA seronegative subjects at high risk for HIV-1 infection. The presence of HIV-1 envelopeantibody in urine but not in blood suggests that, in some subjects, the immune response to HIV-1 may be compartmentalized, as in this example, to the urogenital tract.
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