|
本帖最后由 moveon 于 2011-1-8 15:10 编辑
http://www.medhelp.org/posts/HIV ... for-all/show/255693
by H. Hunter Handsfield, M.D., Aug 02, 2006 12:00AM
Sorry, but there is no such thing as "once and for all" on the window period. There are only estimates for the serconversion window. That's because you can't ethically do the experiment to know for sure, to inoculate people with HIV and see exactly how long it takes. Extrapolating from animal studies (which are particularly expensive if in primates) may not apply to humans. Most newly HIV infected people do not know exactly which of several possible exposures was the source of infection--and even when that information is known, the exact seroconversion window cannot be known unless the exposed person is tested every day for a few weeks, which is never done. Therefore, all statements about the seroconversion window are estimates; and because they are only estimates, different experts come up with different numbers.
Good luck-- HHH, MD
抱歉,对于窗口期,是没有一个明确的硬杠杠的。窗口期永远也只可能是一个估计值。因为你无法对每一个感染者从行为到检测到血清的转换等细节进行一个明确的实验和研究。而在动物身上的实验对于人来说又有很大的差异,也不一定准确。大多数感染的人根本不知道他们明确的感染原因,或者是哪一个具体行为使他们感染。即使他们确定了行为,也无法对他们具体的血清转换时间做一个大量的统计,除非所有感染者都是每天检查一次。。。这也是不可能。因此,对于窗口期来说,我们目前的定义是基于一个估计值,一个建立在大量人群的观察上的,总结了来自不同学者的学术研究的一个相对保守和准确的值。所以才会发生不同的机构和学者也许会给出不同的窗口期。
好运,HHH,MD
---------------------------------------------------
话又说回来,美国,英国,我国包括其他大量发达国家的官方窗口期都比较保守,基本都是3个月。但是你要知道这些健康机构和CDC等,都是权威的机构,他们一定会用最保守的言辞来确保他们说的没有错才行,因此他们只可能尽可能的保守。由于HIV检测是一个不断发展的科技,在2000年以后3代试剂和4代试剂的普及,窗口期也许确实被缩短了,因为大量研究和统计都发现6-8周检测为阴的人群几乎没有人在3个月后的检测发生血清转换的。那么这个6-8周的定义就是有意义的。但是我仍然推荐,也是CDC医生和我亲口说的,最好3个月复查一次。检测两次也可以排除了实验室和试剂的误差可能。也给自己和家人一个放心。我想说的就这么多。
|
|